Cavinton forte (Vinpocetine)

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Cavinton forte (aka Vinpocetine)

Vinpocetine is an alkaloid of Vinca minor plant obtained from its leaves. It is marketed as a drug under “Cavinton” and “Cavinton forte” trade names since 1970s. Vinpocetine also widely used in a variety of nootropic proprietary blends that you can find on Amazon.

Vinpocetine is a cerebral vasodilator, which means it is intended to improve cerebral blood flow and is used to treat cerebrovascular disorders. The vasodilatory action of Cavinton is mediated by smooth muscle relaxation and blood viscosity decrease. The drug is also shown to increase oxygen and glucose uptake in the brain and does provide moderate neuroprotective effect through sodium channels inhibition.

Indications for use are:

  • Cerebrovascular disorders
  • Retinal vascular disorders
  • Macular degeneration
  • Secondary glaucoma
  • Meniere's disease and Tinnitus

Dosage and administration

The recommended dosage is 5-10mg three times a day after a meal. The initial daily dose is 15mg; the maximum daily dose is 30mg. The length of the treatment course can be up to three months. It is recommended to decrease the dose gradually before cessation. The course can be repeated 2-3 times annually.

Side effects

  • Labile arterial tension
  • Tachycardia
  • Insomnia/sleepiness
  • Vertigo
  • Headaches
  • Drowsiness
  • Sweating
  • Nausea
  • Allergic reactions

Contraindications

  • Hypersensitivity
  • Hemorrhagic stroke in the acute stage
  • Ischemic heart disease
  • Heart rhythm disorders
  • Pregnancy and lactation
  • Age below 18 years old
  • Lactose intolerance

Drug interactions

Does not interact with beta-blockers (Cloranolol, Pindolol), Clopamide, Glibenclamide, Digoxin, Acenocoumarol, Hydrochlorothiazide, Imipramine.

The drug does potentiate the hypotensive effect of Methyldopa.

Despite the lack of data confirming the interaction, Vinpocetine should be used cautiously if coadministered with drugs with central, antiarrhythmic and anticoagulant action