Donormyl (doxylamine succinate) is one of the most popular antihistamine sleep aids. It works by inhibiting histamine receptors and have significant sedative effect.
As a solution for insomnia, Donormyl has a several advantages over benzodiazepines. Donormyl does not negatively affect the quality of sleep, and does not cause dependence.
According to studies, the sleep-inducing effect of Doxylamine is comparable to secobarbital (a potent barbiturate).
Indication for use is insomnia. The drug also used in combination with pyridoxine in the treatment of nausea and morning sickness.
Recommended dosage is 15mg, 15 minutes prior to bedtime. The dosage can be raised to 30mg if necessary. The length of the treatment course is 2-5 days.
Contraindications for use are:
Hypersensitivity to the drug.
Prostatic hyperplasia and urinary retention.
Age below 15 years old.
Possible side effects include daytime sleepiness, dry mouth, accommodative paresis, constipation and urinary retention.
Donormyl can potentiate the effects of barbiturates, benzodiazepines, clonidine, opioids and antipsychotics. Coadministration with other anticholinergic drugs may increase the frequency of side effects. It is not recommended to take Donormyl with alcohol, as it can increase the sedative effect.