Noben [Idebenone]

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Idebenone

Noben (Idebenone) is a nootropic drug used to treat various neurological disorders. It is a synthetic derivative of Coenzyme Q10, an endogenous compound involved in mitochondrial energy production.

Idebenone was developed in 1980’s by Takeda Pharmaceuticals for the treatment of cognitive dysfunctions and Alzheimer’s disease.

The pharmacological action of Idebenone is based on its antioxidant and neuroprotective properties. The drug protects cell membranes and mitochondria from oxidative damage, prevent excitotoxicity, and promote the generation of ATP.

Indications for use are:

  • Organic brain syndrome
  • Memory and attention impairments
  • Decreased mental capacity
  • Emotional lability
  • Asthenia (chronic fatigue) and mild depression
  • Headaches, vertigo, and tinnitus

Dosage and administration

The recommended dosage is one capsule 2-3 times a day. The length of the treatment course is 1.5-2 months. The course can be repeated 2-3 times annually.

Side effects

  • Allergic reactions
  • Insomnia
  • Indigestion
  • Headaches
  • Agitation

Contraindications

  • Hypersensitivity
  • Pregnancy and lactation
  • Age below 18 years old
  • Chronic renal insufficiency