Metaprot (Bemitil)

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Metaprot (aka Bemitil)

Bemitil, also known as Metaprot, is the reference drug of actoprotectors class. Actoprotectors are the substances that are intended to improve physical performance of people exposed to stressful conditions, such as high physical loads, heat exposure, and hypoxia.

Bemitil was developed in the 1970s by Soviet scientists for application in the military medicine. It was used during Afghanistan war, Chernobyl catastrophe and Moscow Olympic Games in 1980.

Currently, Metaprot is used in medicine to treat asthenic conditions (chronic fatigue). It is often used recreationally to improve cognitive functions and physical performance. Metaprot does potentiate the therapeutic effect of nootropic drugs such as Piracetam, thus it can be used as a part of efficient nootropic stack.

You can read more about actoprotectors and their mechanism of action in this article.

Dosage and administration

The recommended dosage for adults with body mass less than 180lbs – two capsules in the morning and one capsule in the daytime. For individuals with body mass above 180lbs, the dosage is two capsules in the morning and two in the daytime.

The drug should be cycled by 5-day courses with 2 days off. To increase the physical performance in extreme conditions, the drug should be taken 40-60 minutes prior to stress exposure at 500-750mg dosage. Metaprot should not be taken for more than two week-long cycles.

Side effects

  • Headaches
  • Insomnia
  • Anxiety
  • Hyperaemia
  • Hypertension
  • Nausea
  • Allergic reactions

Drug interactions

Hepatic microsomal enzymes inhibitors of CYP1A2, CYP2C9, CYP2D6, CYP3A4 (e.g Cimetidine) does increase drug concentration in the blood.

Coadministration with Inosine, Piracetam, Trimetazidine, potassium and magnesium asparaginate, glutamic acid, alpha-Tocopherol, nitrates and beta-blockers does potentiate their effects.

It is not recommended to take Metaprot for people with suicidal thoughts.

Contraindications

  • Hypersensitivity
  • Hypoglycemia
  • Liver disorders
  • Epilepsy
  • Psychomotor agitation
  • Arterial hypertension
  • Glaucoma
  • Ischemic heart disease
  • Arrhythmia
  • Lactose intolerance
  • Pregnancy and lactation
  • Age below 18 years old