Mexidol (emoxypine succinate)

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Mexidol (emoxypine succinate)

Mexidol (Emoxypine succinate) is a Russian nootropic drug with a primarily antioxidant action. It was developed in the Soviet Union in 1980’s and is currently being used in Russian medicine to treat various neurological conditions as well as some cardiac disorder.

Mexidol has anxiolytic, nootropic, antioxidant, and neuroprotective action. The neuroprotective effect of Emoxypine is mediated by its ability to inhibit free radical oxidation and increase the activity of endogenous antioxidant enzymes. The drug is also shown to restore the sensitivity of acetylcholine and GABA receptors to their endogenous ligands, thus producing anxiolytic and nootropic effects.

One of the most important properties of Mexidol is its ability to mitigate the neurological manifestations of alcohol intoxication.

Indications for use are:

  • Cognitive dysfunctions of various etiologies
  • Age-related memory and cognition impairments
  • Anxiety disorders
  • Alcohol abstinence syndrome
  • Exposure to stressful conditions
  • Adjunctive therapy of ischemic heart disease

Dosage and administration

The dosage is 1-2 pills 2-3 times a day for 2-6 weeks. The duration of the treatment course for alcohol withdrawal relief is 5-7 days. After finishing the course, slowly taper off the dose over 2-3 days.

Side effects

  • Indigestion
  • Allergic reactions

Contraindications

  • Acute liver and renal insufficiency
  • Hypersensitivity
  • Age below 18 years old
  • Pregnancy and lactation