Mildronate (Meldonium) is a Soviet anti-ischemic drug primarily used to protect the heart from ischemic damage.
It was developed in the 1970’s in Latvia. At first, it supposed to be a cattle growth promoting compound. Later on, it was discovered that Mildronate has a better usage. Currently, it is used to treat ischemic heart disease, cerebrovascular disorders, and asthenia (aka chronic fatigue).
Mildronate often used recreationally by many people as a performance enhancer, especially by athletes (17% of Russian athletes were Meldonium-positive in 2015). Needless to say that if you are a professional athlete, Mildronate may not suit you well as it is banned by WADA.
Meldonium works by inhibiting carnitine biosynthesis, thus preventing accumulation of fatty acid oxidation byproducts in tissues.
Indications for use are:
- Ischemic heart disease
- Cerebrovascular disorders
- Decreased mental and physical capacity
- Alcohol abstinence syndrome
Dosage and administration
The recommended dosage depends on diagnosis:
- The dosage for Ischemic heart disease and cerebrovascular disorders is 500-1000mg daily, either in single or by two separate doses. The length of the treatment course is 4-6 weeks.
- The dosage for performance increase is 500mg twice daily for 10-14 days. The course can be repeated in 2-3 weeks if necessary. For injection form, the dose is 5ml taken either by IV or IM injection once daily for 10-14 days.
- The dosage for alcohol abstinence syndrome is 500mg four times a day for 7-10 days.
- Allergic reactions
- Increased/decreased arterial pressure
- Increased intracranial pressure
- Age below 18 years old
- Pregnancy and lactation