Nootropil [Piracetam]

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nootropil

Piracetam is a GABA derivative and the reference nootropic drug. It is used since 1960’s to treat various cognitive dysfunctions caused by organic brain disorders.

As of today, Piracetam is used in the medical practice of Russia and several European countries. It is also often marketed as a cognitive-enhancing supplement.

The exact mechanism of action of Piracetam is not fully understood. It is suggested that the drug increases the oxygen and glucose consumption in the brain and acts as a positive allosteric modulator of AMPA receptors.

Indications for use are:

  • Symptomatic treatment of organic brain syndrome, such as age-related memory and attention impairments
  • Ischemic stroke
  • Alcohol abstinence syndrome and cognitive impairments caused by chronic alcoholism
  • Traumatic brain injuries
  • Vertigo
  • Adjunctive therapy of learning disabilities in children

It is recommended to take Piracetam alongside with choline supplementation, as they have a synergistic effect.

Further reading about Piracetam and its mechanism of action

Dosage and administration

The dosage for symptomatic treatment of cognitive impairments into 2.4-4.8 grams a day, split in 2-3 doses, taken with a meal or on an empty stomach. To avoid sleep disturbances, do not take Piracetam after 5 PM.

Side effects

  • Nervous system: hyperkinesis, irritability, sleepiness, depression, fatigue, headaches, vertigo, insomnia, agitation, anxiety, tremor, ataxia, complications of epilepsy, hallucinations, delirium, hypersexuality.
  • Digestive system: nausea, diarrhea, abdominal pain.
  • Allergic reactions
  • Hypertension
  • Hypotension
  • Weight gain

Contraindications

  • Hypersensitivity
  • Hemorrhagic stroke
  • Terminal stage of renal insufficiency
  • Pregnancy and lactation
  • Age below 1 years old