Tiocetam

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Tiocetam

Tiocetam is a combined nootropic drug that consists of Piracetam and Thiotriazoline.

Piracetam is the reference nootropic drug that is used in medicine since 1960’s. It has a broad range of indications including traumatic brain injuries, cerebrovascular disorders, and cognitive impairments. Piracetam also often used recreationally as a cognitive enhancer, although its effect on healthy individuals is subtle.

Thiotriazoline is a novel drug with hepatoprotective, membrane stabilizing, anti-ischemic, antioxidant, and immunomodulating action. It was developed in 1980’s in Ukraine and is available on the market since 1994. As a standalone drug, Thiotriazoline is used in the treatment of various cardiac and liver diseases.

The indications for use of Tiocetam include ischemic stroke, vascular/toxic/traumatic encephalopathies and alcohol abstinence syndrome.

Dosage and administration

The dosage for symptomatic treatment of cognitive impairments in patients with cerebrovascular disorders is two pills three times a day before meal for 25-30 days.

The dosage for patients with toxic and diabetic encephalopathies is two pills three times a day before meal for 45 days.

Patients with renal insufficiency should receive a lower dose.

Side effects

According to postmarketing surveillance, Tiocetam rarely causes any side effects, however, some users may experience:

  • Allergic reactions
  • Drowsiness
  • Nausea
  • Agitation
  • Anxiety
  • Hallucinations
  • Diarrhea
  • Dry mouth
  • Vertigo
  • Hyperkinesia
  • Weight gain

Contraindications

  • Hypersensitivity
  • Terminal stage of renal insufficiency
  • Hemorrhagic stroke
  • Huntington's disease
  • Pregnancy and lactation